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- Title
Genetic variants of the copy number polymorphic beta-defensin locus are associated with sporadic prostate cancer.
- Authors
Huse, Klaus; Taudien, Stefan; Groth, Marco; Rosenstiel, Philip; Szafranski, Karol; Hiller, Michael; Hampe, Jochen; Junker, Kerstin; Schubert, Jorg; Schreiber, Stefan; Birkenmeier, Gerd; Krawczak, Michael; Platzer, Matthias
- Abstract
Prostate cancer represents the cancer with the highest worldwide prevalence in men. Chromosome 8p23 has shown suggestive genetic linkage to early-onset familial prostate cancer and is frequently deleted in cancer cells of the urogenital tract. Within this locus some beta-defensin genes (among them DEFB4, DEFB103, DEFB104) are localized, which are arranged in a gene cluster shown to exhibit an extensive copy number variation in the population. This structural variation considerably hampers genetic studies. In a new approach considering both sequence as well as copy number variations we aimed to compare the defensin locus at 8p23 in prostate cancer patients and controls.
- Publication
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2008, Vol 29, Issue 2, p83
- ISSN
1423-0380
- Publication type
Journal Article
- DOI
10.1159/000135688