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- Title
Towards noninvasive molecular fluorescence imaging of the human brain.
- Authors
Steinbrink, J; Liebert, A; Wabnitz, H; Macdonald, R; Obrig, H; Wunder, A; Bourayou, R; Betz, T; Klohs, J; Lindauer, U; Dirnagl, U; Villringer, A
- Abstract
Fluorescence molecular brain imaging is a new modality allowing the detection of specific contrast agents down to very low concentration ranges (picomolar) in disease models. Here we demonstrate a first noninvasive application of fluorescence imaging in the human brain, where concentrations down to about 100 nM of a nonspecific dye were detected. We argue that due to its high sensitivity, optical molecular imaging of the brain is feasible, which - together with its bedside applicability - makes it a promising technique for use in patients.
- Publication
Neuro-degenerative diseases, 2008, Vol 5, Issue 5, p296
- ISSN
1660-2862
- Publication type
Journal Article
- DOI
10.1159/000135614