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- Title
Higher Serum Vitamin D<sub>3</sub> Levels Are Associated with Better Cognitive Test Performance in Patients with Alzheimer’s Disease.
- Authors
Oudshoorn, C.; Mattace-Raso, F. U. S.; Van der Velde, N.; Colin, E. M.; Van der Cammen, T. J. M.
- Abstract
Background/Aims: Recent studies suggest that vitamin D metabolites may be important for preserving cognitive function via specific neuroprotective effects. No large studies have examined the association between vitamin D status and cognition. Methods: In this cross-sectional study, we analyzed the serum 25-hydroxyvitamin D3 levels and Mini-Mental State Examination (MMSE) test scores of 225 older outpatients who were diagnosed as having probable Alzheimer’s disease (AD). In addition to the 25-hydroxyvitamin D3 levels, we analyzed the serum vitamin B1, B6 and B12 levels. Results: An association was found between MMSE test scores and serum 25-hydroxyvitamin D3 levels, with a β-coefficient of 0.05 (p = 0.01). Vitamin-D-sufficient patients had significantly higher MMSE scores as compared to vitamin-D-insufficient ones. No association was found with the other serum vitamin levels. Conclusions: These data support the idea that a relationship exists between vitamin D status and cognition in patients with probable AD. However, given the cross-sectional design of this study, no causality can be concluded. Further prospective studies are needed to specify the contribution of vitamin D status to the onset and course of cognitive decline and AD. Copyright © 2008 S. Karger AG, Basel
- Publication
Dementia & Geriatric Cognitive Disorders, 2008, Vol 25, Issue 6, p539
- ISSN
1420-8008
- Publication type
Academic Journal
- DOI
10.1159/000134382