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Title
Interplay between dose and frequency of GnRH administration in determining pituitary gonadotropin responsiveness.
Authors
Hughes, Virginia A; Boepple, Paul A; Crowley, William F, Jr; Seminara, Stephanie B
Abstract
The dose, frequency and contour of GnRH stimulation of the pituitary gonadotrope have been shown to be independent variables influencing pituitary LH secretion. The dynamic interaction between these variables during physiological and pathophysiological states has yet to be examined.