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- Title
Antiglycation and antioxidant effect of carnosine against glucose degradation products in peritoneal mesothelial cells.
- Authors
Alhamdani, Mohamed-Saiel Saeed; Al-Kassir, Abdul-Hameed A-M; Abbas, Fawzi K H; Jaleel, Nidham A; Al-Taee, Maha F
- Abstract
Toxicity with advanced glycation end products (AGEs) is a major problem in uremic patients. Treatment with peritoneal dialysis (PD) exacerbates AGE formation as a result of bioincompatibility of the conventional peritoneal dialysis fluid (PDF). The presence of glucose degradation products (GDPs) in PDF is the main cause of its bioincompatibility. Carnosine is an endogenous dipeptide with a powerful antiglycation/antioxidant activity. In an attempt to improve PDF biocompatibility, we evaluated the effect of carnosine in human peritoneal mesothelial cells (HPMC) incubated with PDF or GDPs in vitro.
- Publication
Nephron. Clinical practice, 2007, Vol 107, Issue 1, pc26
- ISSN
1660-2110
- Publication type
Journal Article
- DOI
10.1159/000106509