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- Title
Blockade of IP-10/CXCR3 promotes progressive renal fibrosis.
- Authors
Nakaya, Izaya; Wada, Takashi; Furuichi, Kengo; Sakai, Norihiko; Kitagawa, Kiyoki; Yokoyama, Hitoshi; Ishida, Yuko; Kondo, Toshikazu; Sugaya, Takeshi; Kawachi, Hiroshi; Shimizu, Fujio; Narumi, Shosaku; Haino, Makoto; Gerard, Craig; Matsushima, Kouji; Kaneko, Shuichi
- Abstract
Fibrosis is a hallmark of progressive organ disease. The 10-kDa interferon-inducible protein IP-10/CXCL10 is a potent chemoattractant for activated T lymphocytes, natural killer cells, and monocytes. However, the involvement of IP-10 in the pathogenesis of renal diseases via its receptor, CXCR3, remains unclear. To contribute to the clarification of this issue was the aim of this study.
- Publication
Nephron. Experimental nephrology, 2007, Vol 107, Issue 1, pe12
- ISSN
1660-2129
- Publication type
Journal Article
- DOI
10.1159/000106505