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- Title
Screening candidate longevity therapeutics using gene-expression arrays.
- Authors
Spindler, Stephen R; Mote, Patricia L
- Abstract
We review studies showing that CR acts rapidly, even in late adulthood, to extend health- and lifespan in mice. These rapid physiological effects are closely linked to patterns of gene expression in liver and heart. Non-human primate and human studies suggest that the signal transduction pathways responsible for the lifespan and health effects of caloric restriction (CR) may also be involved in human longevity. Thus, pharmaceuticals capable of mimicking the effects of CR (and other methods of lifespan extension) may have application to human health.
- Publication
Gerontology, 2007, Vol 53, Issue 5, p306
- ISSN
1423-0003
- Publication type
Journal Article
- DOI
10.1159/000103924