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- Title
Possible Novel Receptor for PGD<sub>2</sub> on Human Bronchial Epithelial Cells.
- Authors
Chiba, Takahito; Kanda, Akira; Ueki, Shigeharu; Ito, Wataru; Yamaguchi, Kazutoshi; Kamada, Yumiko; Takeda, Masahide; Tanigai, Tomomi; Oyamada, Hajime; Kayaba, Hiroyuki; Chihara, Junichi
- Abstract
Prostaglandin D2 (PGD2), a major prostanoid produced by activated mast cells, has long been implicated in allergic diseases. Recent studies have shown that PGD2 exerts its effects through two different G-protein-coupled receptors (GPCRs), the D-prostanoid receptor (DP) and the chemoattractant receptor-homologous molecule expressed on T helper type-2 cells (CRTH2), expressed in various human tissues. The PGD2/CRTH2 system mediates the chemotaxis of eosinophils, basophils, and Th2 cells, which are involved in the induction of allergic inflammation. We have reported that normal human bronchial epithelial cells (NHBE) and epithelial cell lines (NCI-H292) expressed CRTH2, and PGD2 induces production of IL-8 and GM-CSF. This review discusses the role of CRTH2/DP on epithelial cells and mentions a possible novel receptor for PGD2. Copyright © 2007 S. Karger AG, Basel
- Publication
International Archives of Allergy & Immunology, 2007, Vol 143, p23
- ISSN
1018-2438
- Publication type
Academic Journal
- DOI
10.1159/000101400