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Title
Imputation of missing ages in pedigree data.
Authors
Balise, Raymond R; Chen, Yu; Dite, Gillian; Felberg, Anna; Sun, Limei; Ziogas, Argyrios; Whittemore, Alice S
Abstract
In human pedigree data age at disease occurrence frequently is missing and is imputed using various methods. However, little is known about the performance of these methods when applied to families. In particular, there is little information about the level of agreement between imputed and actual values of temporal data and their effects on inferences.