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- Title
Effects of alpha-lipoic acid on the plasma levels of asymmetric dimethylarginine in diabetic end-stage renal disease patients on hemodialysis: a pilot study.
- Authors
Chang, Jai Won; Lee, Eun Kyoung; Kim, Tae Hee; Min, Won Ki; Chun, Sail; Lee, Ki-Up; Kim, Soon Bae; Park, Jung Sik
- Abstract
Endothelial dysfunction due to reduced nitric oxide (NO) availability precedes the development of atherosclerosis. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NO synthase, is not only a cause of endothelial dysfunction, but also a predictor of the cardiovascular outcome in end-stage renal disease (ESRD) patients on hemodialysis (HD). Alpha-lipoic acid (ALA), a strong antioxidant, increases NO-mediated vasodilation in diabetic patients. We investigated whether ALA could decrease the plasma level of ADMA in diabetic ESRD patients on HD.
- Publication
American journal of nephrology, 2007, Vol 27, Issue 1, p70
- ISSN
1421-9670
- Publication type
Journal Article
- DOI
10.1159/000099035