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- Title
Overexpression of the orotate phosphoribosyl-transferase gene enhances the effect of 5-fluorouracil on gastric cancer cell lines.
- Authors
Taomoto, Jyunnya; Yoshida, Kazuhiro; Wada, Yoshiyuki; Tanabe, Kazuaki; Konishi, Kazuo; Tahara, Hidetoshi; Fukushima, Masakazu
- Abstract
Orotate phosphoribosyl-transferase (OPRT) is the initial enzyme of the 5-fluorouracil (5-FU) metabolic pathway, converting 5-FU into 5-fluorouridinemonophosphate, which is the most important mechanism of 5-FU activation. We therefore investigated whether overexpression of the OPRT gene enhances sensitivity to 5-FU.
- Publication
Oncology, 2006, Vol 70, Issue 6, p458
- ISSN
0030-2414
- Publication type
Journal Article
- DOI
10.1159/000098873