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- Title
Association of β-Defensin 1 Single Nucleotide Polymorphisms with Atopic Dermatitis.
- Authors
De Oca, Ernesto Prado-Montes; García-Vargas, Alejandro; Lozano-Inocencio, Reymundo; Gallegos-Arreola, Martha Patricia; Sandoval-Ramírez, Lucila; Dávalos-Rodríguez, Nory Omara; Figuera, Luis Eduardo
- Abstract
Background: Atopic dermatitis (AD) is a chronic multifactorial allergic disease with unclear etiology. The antimicrobial human β-defensin 1 is chemotactic for dendritic cells, which are important regulators of allergic immune responses. In an attempt to identify useful markers that could predict susceptibility to AD, we investigated single nucleotide polymorphisms (SNPs) of the β-defensin 1 gene (DEFB1) with potential functional consequences. Methods: Four SNPs of the DEFB1 gene were genotyped either by real-time polymerase chain reaction or polymerase chain reaction-restriction fragment length polymorphisms in 59 patients with AD and 151 controls from the Mexican population. Correlation analyses were carried out between genetic, environmental and clinical variables in AD patients. Results: The genotypes associated with susceptibility to AD and no other allergy were 692 GG (OR = 3.21, 95% CI 1.37–7.34) and 1654 AA (OR = 17.37, 95% CI 1.62–860.83). The allele 668 C is a risk factor for AD (OR = 2.23, 95% CI 1.22–4.01) and the allele A in site 1836 correlates with earlier age at onset (Spearman’s ρ = 0.232; p = 0.03). The prolonged duration of breastfeeding correlates with earlier age at onset as well as with the severity of AD. Conclusions: The DEFB1 gene is probably involved in the incidence and development of AD, but additional functional studies will be necessary to understand the biological role of these SNPs. Copyright © 2007 S. Karger AG, Basel
- Publication
International Archives of Allergy & Immunology, 2007, Vol 142, Issue 3, p211
- ISSN
1018-2438
- Publication type
Academic Journal
- DOI
10.1159/000097023