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- Title
Factors affecting human IgE and IgG responses to allergen-like Schistosoma mansoni antigens: Molecular structure and patterns of in vivo exposure.
- Authors
Fitzsimmons, Colin M; McBeath, Rowena; Joseph, Sarah; Jones, Frances M; Walter, Klaudia; Hoffmann, Karl F; Kariuki, H Curtis; Mwatha, Joseph K; Kimani, Guchuhi; Kabatereine, Narcis B; Vennervald, Birgitte J; Ouma, John H; Dunne, David W
- Abstract
The human IgE response is associated with allergy and with host defence against parasitic worms. A response to Sm22.6, the dominant IgE antigen in adult Schistosoma mansoni worms, correlates with resistance to re-infection after treatment. Sm22.6 is one of a family of EF-hand containing parasite proteins with sequence similarity to dynein light chain (DLC) and with major non-parasite allergens. Here we compare human IgE and IgG responses to other family members, Sm20.8 and Sm21.7, as well as to SmDLC1, relating these to antigen structure and expression in parasite life stages.
- Publication
International archives of allergy and immunology, 2007, Vol 142, Issue 1, p40
- ISSN
1018-2438
- Publication type
Journal Article
- DOI
10.1159/000095997