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- Title
Beneficial effect of TGFbeta antagonism in treating diabetic nephropathy depends on when treatment is started.
- Authors
Benigni, Ariela; Zoja, Carla; Campana, Marco; Corna, Daniela; Sangalli, Fabio; Rottoli, Daniela; Gagliardini, Elena; Conti, Sara; Ledbetter, Steve; Remuzzi, Giuseppe
- Abstract
In diabetic rats with maximal activation of RAS induced by uninephrectomy, late treatment with anti-TGFbeta antibody limited renal injury only when combined with ACE inhibitor. We investigated whether in a two-kidney diabetic model the time at which treatment started predicted the response to TGFbeta antagonist.
- Publication
Nephron. Experimental nephrology, 2006, Vol 104, Issue 4, pe158
- ISSN
1660-2129
- Publication type
Journal Article
- DOI
10.1159/000094967