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- Title
Tamm-Horsfall protein acts as a general host-defense factor against bacterial cystitis.
- Authors
Raffi, Hajamohideen S; Bates, James M, Jr; Laszik, Zoltan; Kumar, Satish
- Abstract
Tamm-Horsfall protein (THP) is urine's most abundant protein, but its biological function has remained elusive. Recently, THP-deficient (THP(-/-)) mice were shown to have difficulty clearing Escherichia coli from the urinary bladder. It has remained unclear if interaction between THP and E. coli is specific for E. coli or if THP has a versatile ability to clear a variety of bacteria from the bladder, and act as a broad host-defense mechanism against urinary tract infection (UTI). In this study, we examined the role of THP as a protective factor against UTI caused by bacteria other than E. coli, namely Klebsiella pneumoniae and Staphylococcus saprophyticus by determining if the THP(-/-) mouse has difficulty clearing these bacteria from its bladder.
- Publication
American journal of nephrology, 2005, Vol 25, Issue 6, p570
- ISSN
0250-8095
- Publication type
Journal Article
- DOI
10.1159/000088990