We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Metabolic and vascular effects of tumor necrosis factor-alpha blockade with etanercept in obese patients with type 2 diabetes.
- Authors
Dominguez, Helena; Storgaard, Heidi; Rask-Madsen, Christian; Steffen Hermann, Thomas; Ihlemann, Nikolaj; Baunbjerg Nielsen, Dorthe; Spohr, Camilla; Kober, Lars; Vaag, Allan; Torp-Pedersen, Christian
- Abstract
The pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) impairs insulin action in insulin-sensitive tissues, such as fat, muscle and endothelium, and causes endothelial dysfunction. We hypothesized that TNF-alpha blockade with etanercept could reverse vascular and metabolic insulin resistance.
- Publication
Journal of vascular research, 2005, Vol 42, Issue 6, p517
- ISSN
1018-1172
- Publication type
Journal Article
- DOI
10.1159/000088261