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- Title
Multi-glycoside of Tripterygium wilfordii Hook f. ameliorates proteinuria and acute mesangial injury induced by anti-Thy1.1 monoclonal antibody.
- Authors
Wan, Yigang; Gu, Liubao; Suzuki, Koichi; Karasawa, Tamaki; Fujioka, Yumiko; Han, Gi Dong; Koike, Hiroko; Kawachi, Hiroshi; Shimizu, Fujio
- Abstract
Multi-glycoside from Tripterygium wilfordii Hook f. (GTW) is used for various immune and inflammatory diseases including renal diseases represented by mesangial proliferative glomerulonephritis (MsPGN) in China. However, there have been no fundamental studies on the operating mechanism of GTW on MsPGN. The aim of this study is to examine as the first step the effects of GTW on acute injurious process such as mesangial injury and proteinuria in an acute and reversible Thy.1.1 glomerulonephritis (Thy1.1GN) model and then to clarify the action mechanism of GTW at molecular level by examining its effects on various injurious factors in this model.
- Publication
Nephron. Experimental nephrology, 2005, Vol 99, Issue 4, pe121
- ISSN
1660-2129
- Publication type
Journal Article
- DOI
10.1159/000083980