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- Title
ICAM G241A polymorphism and soluble ICAM-1 serum levels: evidence for an active immune process in schizophrenia.
- Authors
Kronig, Holger; Riedel, Michael; Schwarz, Markus J; Strassnig, Martin; Moller, Hans-Jurgen; Ackenheil, Manfred; Muller, Norbert
- Abstract
We have previously reported reduced serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) in schizophrenic patients. A single-nucleotide polymorphism (SNP) of the ICAM-1 gene was described at position 241. The G-->A SNP results in a nonsynonymous amino acid exchange of the ICAM-1 protein, and the A allele was shown to be also associated with several immunological disorders like rheumatoid arthritis.
- Publication
Neuroimmunomodulation, 2005, Vol 12, Issue 1, p54
- ISSN
1021-7401
- Publication type
Journal Article
- DOI
10.1159/000082364