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- Title
Association Study of a Functional Catechol-O-Methyltransferase Genetic Polymorphism with Age of Onset, Cognitive Function, Symptomatology and Prognosis in Chronic Schizophrenia.
- Authors
Shih-Jen Tsai; Chen-Jee Hong; Ding-Lieh Liao; I-Ching Lai; Ying-Jay Liou
- Abstract
The gene coding for catechol-O-methyltransferase (COMT), which is involved in the metabolism of catecholamines, has long been implicated as a candidate gene for schizophrenia.This study aimed to assess the relationship between a functional polymorphism (Val158Met) of the COMT gene and age of onset (AOO), symptomatology, global cognitive function and prognosis in patients with schizophrenia. The study enrolled 154 patients with schizophrenia from chronic wards. Results failed to show a significant association between the Vall58Met polymorphism and the Brief Psychiatric Rating Scale scores, Mini-Mental State Examination scores, and Social and Occupational Functioning Assessment Scale scores, but COMT Val158Met heterozygotes had a later AOO than homozygous patients. However, by further expanding the number of patients to 228 patients, the differences in AOO among thethree COMT genotypicgroupswas not significant. The COMTVaI158Met polymorphism did not appearto significantly affect susceptibility, symptomatology, global cognitive function and prognosis in Chinese patients with schizophrenia, but the possible association with AOO merits further investigation.
- Publication
Neuropsychobiology, 2004, Vol 49, Issue 4, p196
- ISSN
0302-282X
- Publication type
Academic Journal
- DOI
10.1159/000077366