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- Title
High dose allergen stimulation of T cells from house dust mite-allergic subjects induces expansion of IFN-gamma+ T Cells, apoptosis of CD4+IL-4+ T cells and T cell anergy.
- Authors
Gardner, Leanne M; O'Hehir, Robyn E; Rolland, Jennifer M
- Abstract
During clinically effective allergen-specific immunotherapy a shift in cytokine dominance from IL-4, IL-5 predominant to IFN-gamma predominant has been observed. As antigen concentration influences Th cell priming, this study aimed to determine the effect of different allergen concentrations on human house dust mite (HDM)-specific T cell production of IL-4 and IFN-gamma, proliferation and apoptosis.
- Publication
International archives of allergy and immunology, 2004, Vol 133, Issue 1, p1
- ISSN
1018-2438
- Publication type
Journal Article
- DOI
10.1159/000075248