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- Title
Insulin and insulin-like growth factor I receptors: similarities and differences in signal transduction.
- Authors
Dupont, J; LeRoith, D
- Abstract
The insulin receptor (IR) and the insulin-like growth factor I receptor (IGF-IR) belong to the same subfamily of receptor tyrosine kinases with two extracellular alpha-subunits and two transmembrane beta-subunits. They share a high similarity of structure and intracellular signalling events. However, the IR and the IGF-IR mediate different effects on metabolism, cell proliferation, apoptosis and differentiation. Although some of the variation can be attributed to a different tissue distribution or subcellular localization, it can also be explained by structural differences in the beta-subunit, which may result in activation of specific substrates and signal pathways.
- Publication
Hormone research, 2001, Vol 55 Suppl 2, p22
- ISSN
0301-0163
- Publication type
Journal Article
- DOI
10.1159/000063469