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- Title
Interferon-alpha therapy following autologous peripheral blood stem cell transplantation for adult T cell leukemia/lymphoma.
- Authors
Fujiwara, Hiroshi; Arima, Naomichi; Akasaki, Yuichi; Ohtsubo, Hideo; Ozaki, Atsuo; Kukita, Toshimasa; Matsushita, Kakushi; Arimura, Kosei; Suruga, Yukio; Wakamatsu, Shinichi; Matsumoto, Tadashi; Hidaka, Shiroh; Eizuru, Yoshito; Tei, Chuwa
- Abstract
In the present report, we describe a case of adult T cell leukemia/lymphoma (ATLL), a 58-year-old woman, successfully treated with interferon (IFN)-alpha following autologous peripheral blood stem cell transplantation (auto-PBSCT). The patient remains in remission with full performance status for more than 12 months. Auto-PBSCT reduced the abdominal lymphoma mass and IFN-alpha eliminated residual tumor cells, possibly through the induction of specific T-cell subsets expressing CD3, CD8 on their surfaces and either IFN-gamma or tumor necrosis factor (TNF)-alpha in cytoplasm. We have treated a total of 4 ATLL patients with auto-PBSCT, including the case presented herein. All other patients treated with auto-PBSCT were not followed by adjuvant chemotherapy or cytokine therapy and relapsed within 3 months after auto-PBSCT. This evidence suggests that the therapeutic success of the present case was attributable to the administration of IFN-alpha immunotherapy following auto-PBSCT.
- Publication
Acta haematologica, 2002, Vol 107, Issue 4, p213
- ISSN
0001-5792
- Publication type
Journal Article
- DOI
10.1159/000058317