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- Title
The human hedgehog-interacting protein gene: structure and chromosome mapping to 4q31.21-->q31.3.
- Authors
Bak, M; Hansen, C; Friis Henriksen, K; Tommerup, N
- Abstract
Hedgehog-interacting protein (Hhip) is a novel regulatory component in the vertebrate hedgehog-signalling pathway. The murine Hhip encodes a type I TM protein that attenuates hedgehog signalling by binding all three mammalian hedgehog proteins. Here we describe the cloning and characterisation of the homologous human hedgehog-interacting protein gene (HHIP). HHIP comprises 13 exons and spans >91kb encoding a protein of 700 aa which shares 94% sequence iden- tity with mouse Hhip. HHIP maps to chromosome 4q31.21--> q31.3. Additionally, we have mapped murine Hhip to chromosome 8.
- Publication
Cytogenetics and cell genetics, 2001, Vol 92, Issue 3-4, p300
- ISSN
0301-0171
- Publication type
Journal Article
- DOI
10.1159/000056918