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- Title
Nuclear hormone receptors and mouse skin homeostasis: implication of PPARbeta.
- Authors
Michalik, L; Desvergne, B; Basu-Modak, S; Tan, N S; Wahli, W
- Abstract
PPARbeta is expressed in the mouse epidermis during fetal development, and progressively disappears from the interfollicular epidermis after birth. Interestingly, its expression is strongly reactivated in the adult epidermis in conditions where keratinocyte proliferation is induced and during wound healing. Data obtained on PPARbeta heterozygous mice reveal that PPARbeta is implicated in the control of keratinocyte proliferation and is necessary for rapid healing of a skin wound.
- Publication
Hormone research, 2000, Vol 54, Issue 5-6, p263
- ISSN
0301-0163
- Publication type
Journal Article
- DOI
10.1159/000053269