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- Title
ARHI/NOEY2 inactivation may be important in breast tumor pathogenesis.
- Authors
Hisatomi, Hisashi; Nagao, Kumi; Wakita, Kazuyuki; Kohno, Norio
- Abstract
Allelic loss frequently occurs on the short arm of chromosome 1 in human breast carcinoma, suggesting that the ARHI/NOEY2 gene, an imprinted putative tumor suppressor gene, is involved in the pathogenesis of the tumor entity. To clarify the clinical importance of ARHI/NOEY2 mRNA in breast cancer, we studied whether ARHI/NOEY2 inactivation might contribute to tumors arising in the breast. An ARHI/NOEY2 message was detected by real-time PCR analysis in all noncancerous breast tissues, but was not detected in 2 of 26 breast cancer tissue samples. In 10 of 26 breast cancer tissue samples ARHI/NOEY2 mRNA was substantially reduced. ARHI/NOEY2 expression was lost or markedly reduced in 12 of 26 (46.15%) breast cancer tissue samples. In summary, we conclude that decreased ARHI/NOEY2 mRNA expression may play an important role in the pathogenesis of breast cancer.
- Publication
Oncology, 2002, Vol 62, Issue 2, p136
- ISSN
0030-2414
- Publication type
Journal Article
- DOI
10.1159/000048259