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- Title
Effects of Thalidomide on the Expression of Adhesion Molecules in Rat Liver Cirrhosis.
- Authors
Peng Lv; Paul, Shelley Chireyath; Yanjv Xiao; Shiquan Liu; Hesheng Luo
- Abstract
This study was to evaluate the effects of thalidomide on expression of adhesion molecules in liver cirrhosis. The cirrhosis was induced in Wistar rats by intraperitoneal injection of CCl4, and thalidomide (10 mg/kg/day or 100 mg/kg/day) was given by intragastric administration for 8 weeks. Liver histopathology and immunohistochemistry were significantly improved and the expressions of ICAM-1, VCAM-1, E-selectin, and TNF-α mRNA and protein were decreased significantly in rats treated with a high dose of thalidomide. Close positive correlation was observed in the expression of the TNF-α mRNA and that of ICAM-1, VCAM-1, and Eselectin mRNA, respectively. These results indicate that thalidomide exerts its effect on the downregulation of adhesion molecules via TNF-α signaling pathway to inhibit liver fibrosis.
- Publication
Mediators of Inflammation, 2006, Vol 2006, p1
- ISSN
0962-9351
- Publication type
Academic Journal
- DOI
10.1155/MI/2006/93253