We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Therapeutic Effects of PADRE-BAFF Autovaccine on Rat Adjuvant Arthritis.
- Authors
Guo-dong Feng; Xiao-chang Xue; Mei-li Gao; Xian-feng Wang; Zhen Shu; Nan Mu; Yuan Gao; Zeng-lu Wang; Qiang Hao; Wei-na Li; Meng Li; Cun Zhang; Wei Zhang; Ying-qi Zhang
- Abstract
B cell activating factor (BAFF) is a cytokine of tumor necrosis factor family mainly produced by monocytes and dendritic cells. BAFF can regulate the proliferation, differentiation, and survival of B lymphocytes by binding with BAFF-R on B cell membrane. Accumulating evidences showed that BAFF played crucial roles and was overexpressed in various autoimmune diseases such as systemic lupus erythematous (SLE) and rheumatoid arthritis (RA). This suggests that BAFF may be a therapeutic target for these diseases. In the present study, we developed a BAFF therapeutic vaccine by coupling a T helper cell epitope AKFVAAWTLKAA (PADRE) to the N terminus of BAFF extracellular domains (PADRE-BAFF) and expressed this fusion protein in Escherichia coli. The purified vaccine can induce high titer of neutralizing BAFF antibodies and ameliorate the syndrome of complete Freund's adjuvant (CFA) induced rheumatoid arthritis in rats. Our data indicated that the BAFF autovaccine may be a useful candidate for the treatment of some autoimmune diseases associated with high level of BAFF.
- Publication
BioMed Research International, 2014, Vol 2014, p1
- ISSN
2314-6133
- Publication type
Academic Journal
- DOI
10.1155/2014/854954