Title

Application of Hydrotropic Solubilization in Spectrophotometric Estimation of Lornoxicam from Tablets.

Authors

Abraham, Sindhu; Deveswaran, Rajamanickam; Furtado, Sharon; Bharath, Srinivasan; Madhavan, Varadharajan

Abstract

Lornoxicam is a selective cyclooxygenase-1 and cyclooxygenase-2 inhibitor that exhibits anti-inflammatory, analgesic, and antipyretic activities. It is used in osteoarthritis and rheumatoid arthritis; and in treatment of postoperative pain and primary dysmenorrhoea. Lornoxicam is completely insoluble in water but soluble in alkaline solutions. Hydrotropic solubilization is a technique used to increase the aqueous solubility of poorly water-soluble drugs and the present study was aimed at developing a hydrotropic technique to increase the solubility of lornoxicam, using 2 M sodium benzoate as the hydrotropic agent. Beer's law was obeyed in the concentration range of 4-24 µg/mL at 381 nm. The solubility of lornoxicam in distilled water considerably increased with the addition of a hydrotropic agent. The analysis of tablets indicated good correlation between the amounts estimated and label claim. The LOD and LOQ of lornoxicam were found to be 0.34 µg/mL and 1.038 µg/mL, respectively, indicating good sensitivity of the proposed method. The percentage recovery was found to be 99.99%-100.21%. Thus the proposed method is new, simple, environmentally friendly, accurate, and cost effective and can be successfully employed in routine analysis of lornoxicam in tablets.

Subjects

PIROXICAM; SOLUBILIZATION; SPECTROPHOTOMETRY; DRUG tablets; CYCLOOXYGENASE inhibitors; ANTI-inflammatory agents; RHEUMATOID arthritis treatment

Publication

ISRN Otolaryngology, 2014, p1

ISSN

2090-5742

Publication type

Academic Journal

DOI

10.1155/2014/810128