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- Title
A versatile star PEG grafting method for the generation of nonfouling and nonthrombogenic surfaces.
- Authors
Thalla, Pradeep Kumar; Contreras-García, Angel; Fadlallah, Hicham; Barrette, Jérémie; De Crescenzo, Gregory; Merhi, Yahye; Lerouge, Sophie
- Abstract
Polyethylene glycol (PEG) grafting has a great potential to create nonfouling and nonthrombogenic surfaces, but present techniques lack versatility and stability. The present work aimed to develop a versatile PEG grafting method applicable to most biomaterial surfaces, by taking advantage of novel primary amine-rich plasma-polymerized coatings. Star-shaped PEG covalent binding was studied using static contact angle, X-ray photoelectron spectroscopy (XPS), and quartz crystal microbalance with dissipation monitoring (QCM-D). Fluorescence and QCM-D both confirmed strong reduction of protein adsorption when compared to plasma-polymerized coatings and pristine poly(ethyleneterephthalate) (PET). Moreover, almost no platelet adhesion was observed after 15 min perfusion in whole blood. Altogether, our results suggest that primary amine-rich plasma-polymerized coatings offer a promising stable and versatile method for PEG grafting in order to create nonfouling and nonthrombogenic surfaces and micropatterns.
- Publication
BioMed research international, 2013, Vol 2013, p962376
- ISSN
2314-6141
- Publication type
Journal Article
- DOI
10.1155/2013/962376