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- Title
CD8<sup>+</sup>CXCR5<sup>+</sup> T Cells Regulate Pathology in the Genital Tract.
- Authors
Jiang, Janina; Champion, Cheryl I.; Bo Wei; Guangchao Liu; Kelly, Kathleen A.
- Abstract
We have identified a CD8+CXCR5+ T cell that prevents the development of oviduct dilation following C. muridarum genital infection. Phenotypic studies show that CD8+CXCR5+ cells express markers ofT regulatory cells (FoxP3, CD25, and GITR) but do not express a necessary component of cytotoxic cells (perforin). Cxcr5-/- mice have significantly lower numbers of CD8+ cells and lack the CD8+ CXCR5+ population while the total number of CD4+ cells is equivalent between mouse strains. The transfer of CD8+ splenocytes from WT mice reduces the oviduct dilation seen in Cxcr5-/- mice following C. muridarum infection. Future studies will investigate the mechanism by which this cell type regulates genital tract pathology.
- Publication
Infectious Diseases in Obstetrics & Gynecology, 2013, p1
- ISSN
1064-7449
- Publication type
Academic Journal
- DOI
10.1155/2013/813238