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- Title
Comparing effects of BK virus agnoprotein and herpes simplex-1 ICP47 on MHC-I and MHC-II expression.
- Authors
Cioni, Michela; Mittelholzer, Christian; Wernli, Marion; Hirsch, Hans H
- Abstract
Among human polyomaviruses, only BK virus (BKV) and JC virus (JCV) encode an agnoprotein upstream of VP1 on the viral late transcript. BKV agnoprotein is abundantly expressed late in the viral life cycle, but specific cellular and humoral immune responses are low or absent. We hypothesized that agnoprotein might contribute to BKV immune evasion by downregulating HLA expression, similar to Herpes simplex virus-1 ICP47.
- Publication
Clinical & developmental immunology, 2013, Vol 2013, p626823
- ISSN
1740-2530
- Publication type
Journal Article
- DOI
10.1155/2013/626823