We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Evaluation of the Potential Sensitization of Chlorogenic Acid: A Meta-Analysis.
- Authors
Mingbao Lin; Wan Gong; Qian Chen; Lijuan Sun; Yingchao Wang; Xiaohui Fan
- Abstract
Chlorogenic acid (CGA) widely exists in many plants, which are used as medicinal substances in traditional Chinese medicine injectables (TCMIs) that have been widely applied in clinical treatments. However, it is still controversial whether CGA is responsible for TCMIs-related hypersensitivity. Several studies have been performed to evaluate its potential sensitization property, but the results were inconclusive. Therefore, the aim of this study was to evaluate its potential sensitization systematically using metaanalysis based on data extracted from literatures, searching databases of PubMed, EMBASE, ISI Web of Knowledge, CNKI, VIP, and CHINAINFO from January 1979 to October 2012, a total of 108 articles were retrieved by electronic search strategy, out of which 13 studies met the inclusion criteria. In ASA test, odds ratio of behavior changes was 4.33 (1.62,11.60), showing significant changes after CGA treatment (P = 0.004). Serum IgG, serum histamine, PLN cellularity, and IgGl AFCs were significantly enhanced after CGA treatment (P < 0.05). Totally, these results indicated that CGA could induce a positive reaction in potential sensitization, and intravenous administration of it might be a key factor for sensitization triggering, which could at least warrant more careful application of TCMIs containing CGA in clinical practices.
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2013, Vol 2013, p1
- ISSN
1741-427X
- Publication type
Academic Journal
- DOI
10.1155/2013/208467