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- Title
Biological Activities and Chemical Characterization of Cordia verbenacea DC. as Tool to Validate the Ethnobiological Usage.
- Authors
Fagner Ferreira Matias, Edinardo; Alves, Erivânia Ferreira; Santos, Beatriz Sousa; de Souza, Celestina Elba Sobral; de Alencar Ferreira, João Victor; de Lavor, Anne Karyzia Lima Santos; Figueredo, Fernando Gomes; de Lima, Luciene Ferreira; dos Santos, Francisco Antonio Vieira; Sampaio Neves Peixoto, Flórido; Colares, Aracélio Viana; Boligon, Aline Augusti; de Aquino Saraiva, Rogério; Athayde, Margareth Linde; da Rocha, Joâo Batista Teixeira; Menezes, Irwin Rose Alencar; Douglas Melo Coutinho, Henrique; da Costa, José Galberto Martins
- Abstract
Knowledge of medicinal plants is often the only therapeutic resource of many communities and ethnic groups. "Erva-baleeira," Cordia verbenacea DC, is one of the species of plants currently exploited for the purpose of producing a phytotherapeutic product extracted from its leaves. In Brazil, its major distribution is in the region of the Atlantic Forest and similar vegetation. The crude extract is utilized in popular cultures in the form of hydroalcoholic, decoctions, and infusions, mainly as antimicrobial, anti-inflammatory, and analgesic agents. The aim of the present study was to establish a chemical and comparative profile of the experimental antibacterial activity and resistance modifying activity with ethnopharmacological reports. Phytochemical prospecting and HPLC analysis of the extract and fractions were in agreement with the literature with regard to the presence of secondary metabolites (tannins and flavonoids). The extract and fraction tested did not show clinically relevant antibacterial activity, but a synergistic effect was observed when combined with antibiotic, potentiating the antibacterial effect of aminoglycosides. We conclude that tests of antibacterial activity and modulating the resistance presented in this work results confirm the ethnobotanical and ethnopharmacological information, serving as a parameter in the search for new alternatives for the treatment of diseases.
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2013, Vol 2013, p1
- ISSN
1741-427X
- Publication type
Academic Journal
- DOI
10.1155/2013/164215