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- Title
Where Do AQP4 Antibodies Fit in the Pathogenesis of NMO?
- Authors
Kinoshita, Makoto; Nakatsuji, Yuji
- Abstract
Recent advances in the field of neuromyelitis optica (NMO) research provided convincing evidence that anti-AQP4 antibody (AQP4-Ab) not only serves as a highly specific disease marker, but also plays an essential role in the pathogenesis of the disease. Although it is now widely recognized that AQP4-Ab induces astrocytic necrosis in a complement-dependent manner, additional triggers are also suspected as a prerequisite for the development of the disease. Unraveling these unresolved aspects of the disease will provide substantial insight into still controversial issues in the pathogenesis of NMO.
- Publication
Multiple sclerosis international, 2012, Vol 2012, p862169
- ISSN
2090-2662
- Publication type
Journal Article
- DOI
10.1155/2012/862169