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- Title
Research on plants for the understanding of diseases of nuclear and mitochondrial origin.
- Authors
Spampinato, Claudia P; Gomez-Casati, Diego F
- Abstract
Different model organisms, such as Escherichia coli, Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, mouse, cultured human cell lines, among others, were used to study the mechanisms of several human diseases. Since human genes and proteins have been structurally and functionally conserved in plant organisms, the use of plants, especially Arabidopsis thaliana, as a model system to relate molecular defects to clinical disorders has recently increased. Here, we briefly review our current knowledge of human diseases of nuclear and mitochondrial origin and summarize the experimental findings of plant homologs implicated in each process.
- Publication
Journal of biomedicine & biotechnology, 2012, Vol 2012, p836196
- ISSN
1110-7251
- Publication type
Journal Article
- DOI
10.1155/2012/836196