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- Title
Putative multifunctional signature of lung metastases in dedifferentiated chondrosarcoma.
- Authors
Malchenko, Sergey; Seftor, Elisabeth A; Nikolsky, Yuri; Hasegawa, Susan L; Kuo, Sean; Stevens, Jeff W; Poyarkov, Stas; Nikolskaya, Tatiana; Kucaba, Tamara; Wang, Min; Abdulkawy, Hakim; Casavant, Thomas; Morcuende, Jose; Buckwalter, Joseph; Hohl, Raymond; Deyoung, Barry; Kernstine, Kemp; Bonaldo, Maria de Fatima; Hendrix, Mary J C; Soares, Marcelo B; Soares, Vera Maria F C
- Abstract
Chondrosarcomas are among the most malignant skeletal tumors. Dedifferentiated chondrosarcoma is a highly aggressive subtype of chondrosarcoma, with lung metastases developing within a few months of diagnosis in 90% of patients. In this paper we performed comparative analyses of the transcriptomes of five individual metastatic lung lesions that were surgically resected from a patient with dedifferentiated chondrosarcoma. We document for the first time a high heterogeneity of gene expression profiles among the individual lung metastases. Moreover, we reveal a signature of "multifunctional" genes that are expressed in all metastatic lung lesions. Also, for the first time, we document the occurrence of massive macrophage infiltration in dedifferentiated chondrosarcoma lung metastases.
- Publication
Sarcoma, 2012, Vol 2012, p820254
- ISSN
1369-1643
- Publication type
Journal Article
- DOI
10.1155/2012/820254