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- Title
Stepwise Increases in Left Ventricular Mass Index and Decreases in Left Ventricular Ejection Fraction Correspond with the Stages of Chronic Kidney Disease in Diabetes Patients.
- Authors
Szu-Chia Chen; Jer-Ming Chang; Wan-Chun Liu; Yi-Chun Tsai; Jer-Chia Tsai; Ho-Ming Su; Shang-Jyh Hwang; Hung-Chun Chen
- Abstract
Aims. Patients with diabetic nephropathy are reported to have a high prevalence of left ventricular structural and functional abnormalities. This study was designed to assess the determinants of left ventricular mass index (LVMI) and left ventricular ejection fraction (LVEF) in diabetic patients at various stages of chronic kidney disease (CKD). Methods. This cross-sectional study enrolled 285 diabetic patients with CKD stages 3 to 5 from our outpatient department of internalmedicine. Clinical and echocardiographic parameters were compared and analyzed. Results.We found a significant stepwise increase in LVMI (P < 0.001), LVH (P < 0.001), and LVEF < 55% (P = 0.013) and a stepwise decrease in LVEF (P = 0.038) corresponding to advance in CKD stages. Conclusions. Our findings suggest that increases in LVMI and decreases in LVEF coincide with advances in CKD stages in patients with diabetes.
- Publication
Experimental Diabetes Research, 2012, p1
- ISSN
1687-5214
- Publication type
Academic Journal
- DOI
10.1155/2012/789325