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- Title
p53 Family: Role of Protein Isoforms in Human Cancer.
- Authors
Jinxiong Wei; Zaika, Elena; Zaika, Alexander
- Abstract
TP53, TP63, and TP73 genes comprise the p53 family. Each gene produces protein isoforms through multiple mechanisms including extensive alternative mRNA splicing. Accumulating evidence shows that these isoforms play a critical role in the regulation of many biological processes in normal cells. Their abnormal expression contributes to tumorigenesis and has a profound effect on tumor response to curative therapy. This paper is an overview of isoform diversity in the p53 family and its role in cancer.
- Publication
Journal of Nucleic Acids, 2012, p1
- ISSN
2090-0201
- Publication type
Academic Journal
- DOI
10.1155/2012/687359