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- Title
Mobilization of CD34+CXCR4+ stem/progenitor cells and the parameters of left ventricular function and remodeling in 1-year follow-up of patients with acute myocardial infarction.
- Authors
Wyderka, Rafał; Wojakowski, Wojciech; Jadczyk, Tomasz; Maślankiewicz, Katarzyna; Parma, Zofia; Pawłowski, Tomasz; Musiałek, Piotr; Majka, Marcin; Król, Marek; Kuczmik, Wacław; Dworowy, Sebastian; Korzeniowska, Barbara; Ratajczak, Mariusz Z; Tendera, Michał
- Abstract
Mobilization of stem cells in acute MI might signify the reparatory response. Aim of the Study. Prospective evaluation of correlation between CD34+CXCR4+ cell mobilization and improvement of LVEF and remodeling in patients with acute MI in 1-year followup. Methods. 50 patients with MI, 28 with stable angina (SAP), and 20 individuals with no CAD (CTRL). CD34+CXCR4+ cells, SDF-1, G-CSF, troponin I (TnI) and NT-proBNP were measured on admission and 1 year after MI. Echocardiography and ergospirometry were carried out after 1 year. Results. Number of CD34+CXCR4+ cells in acute MI was significantly higher in comparison with SAP and CTRL, but lower in patients with decreased LVEF ≤40%. In patients who had significant LVEF increase ≥5% in 1 year FU the number of cells in acute MI was significantly higher versus patients with no LVEF improvement. Number of cells was positively correlated (r = 0,41, P = 0,031) with absolute LVEF change and inversely with absolute change of ESD and EDD in 1-year FU. Mobilization of CD34+CXCR4+ cells in acute MI was negatively correlated with maximum TnI and NT-proBNP levels. Conclusion. Mobilization of CD34+CXCR4+ cells in acute MI shows significant positive correlation with improvement of LVEF after 1 year.
- Publication
Mediators of inflammation, 2012, Vol 2012, p564027
- ISSN
1466-1861
- Publication type
Journal Article
- DOI
10.1155/2012/564027