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- Title
Dysregulation of Dicer1 in beta cells impairs islet architecture and glucose metabolism.
- Authors
Mandelbaum, Amitai D; Melkman-Zehavi, Tal; Oren, Roni; Kredo-Russo, Sharon; Nir, Tomer; Dor, Yuval; Hornstein, Eran
- Abstract
microRNAs (miRNAs) play important roles in pancreas development and in regulation of insulin expression in the adult. Here we show that loss of miRNAs activity in beta-cells during embryonic development results in lower beta-cell mass and in impaired glucose tolerance. Dicer1-null cells initially constitute a significant portion of the total beta-cell population. However, during postnatal development, Dicer1-null cells are depleted. Furthermore, wild-type beta cells are repopulating the islets in complex compensatory dynamics. Because loss of Dicer1 is also associated with changes in the distribution of membranous E-cadherin, we hypothesized that E-cadherin activity may play a role in beta cell survival or islet architecture. However, genetic loss of E-cadherin function does not impair islet architecture, suggesting that miRNAs likely function through other or redundant effectors in the endocrine pancreas.
- Publication
Experimental diabetes research, 2012, Vol 2012, p470302
- ISSN
1687-5303
- Publication type
Journal Article
- DOI
10.1155/2012/470302