We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effect of Apheresis for ABO and HLA Desensitization on Anti-Measles Antibody Titers in Renal Transplantation.
- Authors
Schönermarck, Ulf; Kauke, Teresa; Jäger, Gundula; Habicht, Antje; Wendler, Thorsten; Andrassy, Joachim; Guba, Markus; Stangl, Manfred; Fischereder, Michael
- Abstract
Desensitization strategies for ABO-incompatible renal transplants with plasma exchange (PE) or specific immunoadsorption (IA) decrease immunoglobulin levels. After recent measles outbreak and decreasing vaccination rates, we studied the impact of apheresis on anti-measles antibodies. Anti-measles antibodies were measured before desensitization, before transplantation and during followup in 12 patients with ABO incompatibility (2x PE only, 8x IA only, and 2x IA and PE) and 3 patients with donor-specific HLA antibodies (all PE). Patients received rituximab, IVIG, and standard immunosuppressive therapy. All patients had detectable anti-measles antibodies before desensitization (mean 3238 mU/l, range 560-8100). After 3-6 PE sessions, titers decreased significantly to 1710 mU/l (P < 0.05), in one patient to nondetectable values, while IA only maintained protective titers. After a median followup of 64 days, anti-measles antibodies returned to baseline in all patients. Immunity against measles was temporarily reduced by apheresis but remained detectable in most patients at time of transplantation. Desensitization maintains long-term protective immunity against measles.
- Publication
Journal of transplantation, 2011, Vol 2011, p869065
- ISSN
2090-0015
- Publication type
Journal Article
- DOI
10.1155/2011/869065