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- Title
Proteomics in molecular diagnosis: typing of amyloidosis.
- Authors
Loo, Dorothy; Mollee, Peter N; Renaut, Patricia; Hill, Michelle M
- Abstract
Amyloidosis is a group of disorders caused by deposition of misfolded proteins as aggregates in the extracellular tissues of the body, leading to impairment of organ function. Correct identification of the causal amyloid protein is absolutely crucial for clinical management in order to avoid misdiagnosis and inappropriate, potentially harmful treatment, to assess prognosis and to offer genetic counselling if relevant. Current diagnostic methods, including antibody-based amyloid typing, have limited ability to detect the full range of amyloid forming proteins. Recent investigations into proteomic identification of amyloid protein have shown promise. This paper will review the current state of the art in proteomic analysis of amyloidosis, discuss the suitability of techniques based on the properties of amyloidosis, and further suggest potential areas of development. Establishment of mass spectrometry aided amyloid typing procedures in the pathology laboratory will allow accurate amyloidosis diagnosis in a timely manner and greatly facilitate clinical management of the disease.
- Publication
Journal of biomedicine & biotechnology, 2011, Vol 2011, p754109
- ISSN
1110-7251
- Publication type
Journal Article
- DOI
10.1155/2011/754109