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- Title
Successful utilization of high-flux hemodialysis for treatment of vancomycin toxicity in a child.
- Authors
Stidham, Timothy; Reiter, Pamela D; Ford, Douglas M; Lum, Gary M; Albietz, Joseph
- Abstract
Vancomycin is routinely used for empiric antibiotic therapy in children. Higher-serum-concentration targets for serious infections are now being recommended. This recommendation may result in aggressive dosing with increased potential for toxicity. We report a case of a pediatric patient who developed vancomycin toxicity and associated oliguric renal failure who was treated effectively with high-flux hemodialysis for vancomycin toxicity, clearing serum concentrations of vancomycin by over 75% in only 6 hours (213.2 mcg/mL to 51.8 mcg/mL) with subsequent return to baseline renal function and without adverse sequelae. While not historically considered a viable option for drug removal in cases of toxicity, new high-flux hemodialysis techniques can remove significant percentages of vancomycin in short periods of time.
- Publication
Case reports in pediatrics, 2011, Vol 2011, p678724
- ISSN
2090-6811
- Publication type
Case Study
- DOI
10.1155/2011/678724