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- Title
The mechanosensory role of primary cilia in vascular hypertension.
- Authors
Nauli, Surya M; Jin, Xingjian; Hierck, Beerend P
- Abstract
Local regulation of vascular tone plays an important role in cardiovascular control of blood pressure. Aside from chemical or hormonal regulations, this local homeostasis is highly regulated by fluid-shear stress. It was previously unclear how vascular endothelial cells were able to sense fluid-shear stress. The cellular functions of mechanosensory cilia within vascular system have emerged recently. In particular, hypertension is insidious and remains a continuous problem that evolves during the course of polycystic kidney disease (PKD). The basic and clinical perspectives on primary cilia are discussed with regard to the pathogenesis of hypertension in PKD.
- Publication
International journal of vascular medicine, 2011, Vol 2011, p376281
- ISSN
2090-2832
- Publication type
Journal Article
- DOI
10.1155/2011/376281