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- Title
IL-17 in systemic lupus erythematosus.
- Authors
Crispín, José C; Tsokos, George C
- Abstract
IL-17 is a cytokine with powerful proinflammatory activity. Production of IL-17 is abnormally increased in patients with systemic lupus erythematosus (SLE), a multiorgan chronic autoimmune disease. In patients with SLE, CD3+CD4(-)CD8(-) (double negative) T cells are an important source of IL-17. IL-17 produced by double negative and CD4 T cells participates in the pathogenesis of the disease. IL-17-producing T cells are present in the kidneys of patients with lupus nephritis. IL-17 increased production in patients with SLE can amplify the immune response by increasing target organ inflammation and damage and by augmenting the production of antibodies by B cells.
- Publication
Journal of biomedicine & biotechnology, 2010, Vol 2010, p943254
- ISSN
1110-7251
- Publication type
Journal Article
- DOI
10.1155/2010/943254