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- Title
Response to Hydralazine-Valproate in a Patient with Mycosis Fungoides.
- Authors
Due˜nas-Gonzalez, Alfonso; Vega, Maria Teresa; Martinez-Ba˜nos, D´eborah; Garc´ıa-Hidalgo, Linda; Sobrevilla, Pedro
- Abstract
Histone deacetylase (HDAC) inhibitors have shown significant activity in the treatment of cutaneous T-cell lymphomas (CTCL). The epigenetic alterations of CTCL not only are limited to altered histone acetylation but also include aberrant DNA gene methylation hence, the combination of an HDAC inhibitor with a DNA demethylating agent is a promising therapy to be tested. Here we report a mycosis fungoides patient having a dramatic response to hydralazine and valproate, two repositioned drugs as HDAC and DNA methylation inhibitors, respectively.
- Publication
Case Reports in Medicine, 2010, p1
- ISSN
1687-9627
- Publication type
Academic Journal
- DOI
10.1155/2010/657579