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- Title
Tumor Antigen Cross-Presentation and the Dendritic Cell: Where it All Begins?
- Authors
M.McDonnell, Alison; Robinson, BruceW. S.; Currie, Andrew J.
- Abstract
Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that are critical for the generation of effective cytotoxic T lymphocyte (CTL) responses; however, their function and phenotype are often defective or altered in tumor-bearing hosts, which may limit their capacity to mount an effective tumor-specific CTL response. In particular, the manner in which exogenous tumor antigens are acquired, processed, and cross-presented to CD8 T cells by DCs in tumor-bearing hosts is not well understood, but may have a profound effect on antitumor immunity. In this paper, we have examined the role of DCs in the cross-presentation of tumor antigen in terms of their subset, function, migration, and location with the intention of examining the early processes that contribute to the development of an ineffective anti-tumor immune response.
- Publication
Clinical & Developmental Immunology, 2010, p1
- ISSN
1740-2522
- Publication type
Academic Journal
- DOI
10.1155/2010/539519