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- Title
Antibiotic resistance patterns in invasive group B streptococcal isolates.
- Authors
Castor, Mei L; Whitney, Cynthia G; Como-Sabetti, Kathryn; Facklam, Richard R; Ferrieri, Patricia; Bartkus, Joanne M; Juni, Billie A; Cieslak, Paul R; Farley, Monica M; Dumas, Nellie B; Schrag, Stephanie J; Lynfield, Ruth
- Abstract
Antibiotics are used for both group B streptococcal (GBS) prevention and treatment. Active population-based surveillance for invasive GBS disease was conducted in four states during 1996-2003. Of 3813 case-isolates, 91.0% (3471) were serotyped, 77.1% (2937) had susceptibility testing, and 46.6% (3471) had both. All were sensitive to penicillin, ampicillin, cefazolin, cefotaxime, and vancomycin. Clindamycin and erythromycin resistance was 12.7% and 25.6%, respectively, and associated with serotype V (P < .001). Clindamycin resistance increased from 10.5% to 15.0% (X(2) for trend 12.70; P < .001); inducible clindamycin resistance was associated with the erm genotype. Erythromycin resistance increased from 15.8% to 32.8% (X(2) for trend 55.46; P < .001). While GBS remains susceptible to beta-lactams, resistance to alternative agents such as erythromycin and clindamycin is an increasing concern.
- Publication
Infectious diseases in obstetrics and gynecology, 2008, Vol 2008, p727505
- ISSN
1098-0997
- Publication type
Journal Article
- DOI
10.1155/2008/727505