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- Title
POLYKETIDE PRODUCTION BY PLANT-ASSOCIATED PSEUDOMONADS.
- Authors
Bender, CL; Rangaswamy, V; Loper, J
- Abstract
Polyketides constitute a huge family of structurally diverse natural products including antibiotics, chemotherapeutic compounds, and antiparasitics. Most of the research on polyketide synthesis in bacteria has focused on compounds synthesized by Streptomyces or other actinomycetes; however, plant-associated pseudomonads also produce a variety of compounds via the polyketide pathway including the phytotoxin coronatine, the antibiotic mupirocin, and the antifungal compounds pyoluteorin and 2,4-diacetylphloroglucinol. This review focuses on the mode of action, regulation, biosynthesis, and genetics of these four compounds and the potential use of Pseudomonas-derived polyketide synthases in the generation of novel compounds with unique activities.
- Publication
Annual review of phytopathology, 1999, Vol 37, p175
- ISSN
1545-2107
- Publication type
Journal Article
- DOI
10.1146/annurev.phyto.37.1.175