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- Title
Molecular regulation of lung development.
- Authors
Cardoso, W V
- Abstract
There is increasing evidence suggesting that formation of the tracheobronchial tree and alveoli results from heterogeneity of the epithelial-mesenchymal interactions along the developing respiratory tract. Recent genetic data support this idea and show that this heterogeneity is likely the result of activation of distinct networks of signaling molecules along the proximal-distal axis. Among these signals, fibroblast growth factors, retinoids, Sonic hedgehog, and transforming growth factors appear to play prominent roles. We discuss how these and other pattern regulators may be involved in initiation, branching, and differentiation of the respiratory system.
- Publication
Annual review of physiology, 2001, Vol 63, p471
- ISSN
0066-4278
- Publication type
Journal Article
- DOI
10.1146/annurev.physiol.63.1.471